I will have to do some testing to see if Perplex is a good or bad card for this deck. With all the discard, the opponent might just have no cards in his hand, which would negate Perplex's use.
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This looks fun to play. However, on the surface, Manabarbs and all the "tap all lands" cards seem to be a good combo, but does it work? I'm unsure about this, but Manabarbs says "Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player." Aren't you tapping their lands? And isn't it not for mana? Just wondering how that would work.
I put Livewire Lash back in, after evaluating the effects, and replaced Stabbing Pain with Scar (-1/-1 counters as opposed to -1/-1 for the turn. Though it doesn't tap, it is a permanent affect that can grow with proliferate.).
Inkmoth Nexus Land (Rare) T: Add 1 to your mana pool. 1: Inkmoth Nexus becomes a 1/1 Blinkmoth artifact creature with flying and infect until end of turn. It's still a land. This will definitely be making an appearance, though. Four of them. Decimator Web 4 Artifact (Rare) 4, T: Target opponent loses 2 life, gets a poison counter, then puts the top six cards of his or her library into his or her graveyard Ha. Just... ha.
Spread the Sickness, 4B Sorcery (Common) Destroy target creature, then proliferate. This may be too expensive, but is certainly useful. With Plague Myr, it might become quite a bit easier to ramp mana appropriately for the higher-costing proliferation spells. Septic Rats 1BB Creature - Rat (Uncommon) Infect Whenever Septic rats attacks, if defending player is poisoned, it gets +1/+1 until end of turn. 2/2 This is useful, but I feel like it is just more of the same. A potential 3/3 with infect for 3 (converted) is pretty good though. Phyrexian Hydra 3GG Creature - Hydra (Rare) Infect If damage would be dealt to Phyrexian Hydra, prevent that damage. Put a -1/-1 counter on Phyrexian Hydra for each one damage prevented this way. 7/7 This saddens me, it looks like infect is sliding even more toward G/B. With Proliferate, I was hoping that U/B would have the upper hand... perhaps U/G/B is necessary. Then again, though flashy, this Hydra is expensive. Corrupted Conscience 3UU Enchantment - Aura (Uncommon) Enchant Creature You control enchanted creature. Enchanted creature has infect. This may be useful for its control applications, and as an extra infectious oompf.
I'm looking forward to Plague Myr, if the speculative spoilers are accurate: Plague Myr, 2 Artifact Creature - Myr Infect {T}: Add 1 to your mana pool. 1/1 This could easily replace Vector Asp.
Though, on second thought, if I throw Contagion Clasp and Everflowing Chalice in together, they could counteract each other in order to provide mana/proliferate. But I would have to take out creatures, and I need all the infect weenies I can get. Suggestions?
Also, Contagion Clasp, though it seems like it would be very useful, is far too expensive when contrasted with Steady Progress or Thrummingbird. It is a guaranteed poison counter, but could only be useful after at least turn five. I'll sideboard it.
I playtested it against a very difficult mono-black vamp aggro/lifelink deck a friend has, and realized that Inexorable Tide was too expensive to have more than two in the deck. I also needed more cheap infect creatures with some way to avoid being blocked, so I ut in Plague Stinger. Steel Overseer didn't come in handy until late-game, so I put it to the sideboard for now. Distortion Strike was very important, so I bumped it to four, and added Stabbing Pain to get some -1/-1 counters out for the Proliferate as well. With Steel Overseer gone, I switched out Ichorclaw Myr for Necropede for its graveyard-activated ability. Overall, the first edition of the deck was decent, but the struggle was causing the opponent to get that first poison counter. There was too much proliferate, and not enough infect.