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With Laboratory Maniac in the mix, is your goal to deplete your own library or are you looking to mill the opponent?
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try to get both players down to few cards. deplete them, or you if you draw Lab Maniac. It gives you two options to win.
I would worry about trying to mill both you and your opponent at the same time. I would think you would make both take twice as long if you were to split cards to each. I would commit one way or another but that is a personal preference. If you feel you can last long enough to do both, go for it. This is what I went with for self depletion: http://www.mtgvault.com/ViewDeck.aspx?DeckID=328264 Note the self mill spells used. If you were to run some of those, they may be beneficial to one of your win conditions.
i will customize this deck better. if you are facing someone with a big deck, or one who also uses lab maniac, you side in the cards